Individuals with presumably hereditary uveal melanoma do not harbour germline mutations in the coding regions of either the P16(INK4A), P14(ARF) or cdk4 genes

In familial cutaneous malignant melanoma (CMM), disruption of the retinoblastoma (pRB) pathway frequently occurs through inactivating mutations in the p16 (p16(INK4A)/CDKN2A/MTS1) gene or activating mutations in the G1-specific cyclin dependent kinase 4 gene (CDK4). Uveal malignant melanoma (UMM) al...

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Detalhes bibliográficos
Main Authors: Soufir, N, Bressac-de Paillerets, B, Desjardins, L, Lévy, C, Bombled, J, Gorin, I, Schlienger, P, Stoppa-Lyonnet, D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2000
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374387/
https://ncbi.nlm.nih.gov/pubmed/10732752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.1999.1005
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