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Individuals with presumably hereditary uveal melanoma do not harbour germline mutations in the coding regions of either the P16(INK4A), P14(ARF) or cdk4 genes
In familial cutaneous malignant melanoma (CMM), disruption of the retinoblastoma (pRB) pathway frequently occurs through inactivating mutations in the p16 (p16(INK4A)/CDKN2A/MTS1) gene or activating mutations in the G1-specific cyclin dependent kinase 4 gene (CDK4). Uveal malignant melanoma (UMM) al...
Tallennettuna:
| Päätekijät: | , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group
2000
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2374387/ https://ncbi.nlm.nih.gov/pubmed/10732752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.1999.1005 |
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