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Reduced antibody response to streptavidin through site-directed mutagenesis

Streptavidin provides an effective receptor for biotinylated tumoricidal molecules, including radionuclides, when conjugated to an antitumor antibody and administered systemically. Ideally, one would like to administer this bacterial protein to patients repeatedly, so as to maximize the antitumor ef...

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Detalles Bibliográficos
Main Authors: Meyer, Damon L., Schultz, Jody, Lin, Yukang, Henry, Andrew, Sanderson, James, Jackson, Jeffrey M., Goshorn, Steve, Rees, Anthony R., Graves, Scott S.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374127/
https://ncbi.nlm.nih.gov/pubmed/11344318
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