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Correlated conformational fluctuations during enzymatic catalysis: Implications for catalytic rate enhancement

Correlated enzymatic conformational fluctuations are shown to contribute to the rate of enhancement achieved during catalysis. Cytidine deaminase serves as a model system. Crystallographic temperature factor data for this enzyme complexed with substrate analog, transition-state analog, and product a...

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Bibliografiske detaljer
Main Authors: Alper, Kutay O., Singla, Manish, Stone, Jennifer L., Bagdassarian, Carey K.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374110/
https://ncbi.nlm.nih.gov/pubmed/11420434
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