Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1

β-Lactam antibiotics are the mainstay for the treatment of bacterial infections. However, elevated resistance to these antibiotics mediated by metallo-β-lactamases (MBLs) has become a global concern. New Delhi metallo-β-lactamase-1 (NDM-1), a newly added member of the MBL family that can hydrolyze a...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Zhang, Hongmin, Ma, Guixing, Zhu, Yifan, Zeng, Lingxiao, Ahmad, Ashfaq, Wang, Changzhi, Pang, Bo, Fang, Huiyan, Zhao, Liqing, Hao, Quan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201099/
https://ncbi.nlm.nih.gov/pubmed/30150473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01579-18
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