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Enzyme specificity under dynamic control II: Principal component analysis of α-lytic protease using global and local solvent boundary conditions

The contributions of conformational dynamics to substrate specificity have been examined by the application of principal component analysis to molecular dynamics trajectories of α-lytic protease. The wild-type α-lytic protease is highly specific for substrates with small hydrophobic side chains at t...

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Detalles Bibliográficos
Main Authors: Ota, Nobuyuki, Agard, David A.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374101/
https://ncbi.nlm.nih.gov/pubmed/11420442
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