Expanding Proteome Coverage with Orthogonal-specificity α-Lytic Proteases

Bottom-up proteomics studies traditionally involve proteome digestion with a single protease, trypsin. However, trypsin alone does not generate peptides that encompass the entire proteome. Alternative proteases have been explored, but most have specificity for charged amino acid side chains. Therefo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Meyer, Jesse G., Kim, Sangtae, Maltby, David A., Ghassemian, Majid, Bandeira, Nuno, Komives, Elizabeth A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Biochemistry and Molecular Biology 2014
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945911/
https://ncbi.nlm.nih.gov/pubmed/24425750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M113.034710
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