Expanding Proteome Coverage with Orthogonal-specificity α-Lytic Proteases

Bottom-up proteomics studies traditionally involve proteome digestion with a single protease, trypsin. However, trypsin alone does not generate peptides that encompass the entire proteome. Alternative proteases have been explored, but most have specificity for charged amino acid side chains. Therefo...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Meyer, Jesse G., Kim, Sangtae, Maltby, David A., Ghassemian, Majid, Bandeira, Nuno, Komives, Elizabeth A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Biochemistry and Molecular Biology 2014
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945911/
https://ncbi.nlm.nih.gov/pubmed/24425750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M113.034710
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