Expanding Proteome Coverage with Orthogonal-specificity α-Lytic Proteases

Bottom-up proteomics studies traditionally involve proteome digestion with a single protease, trypsin. However, trypsin alone does not generate peptides that encompass the entire proteome. Alternative proteases have been explored, but most have specificity for charged amino acid side chains. Therefo...

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Библиографические подробности
Главные авторы: Meyer, Jesse G., Kim, Sangtae, Maltby, David A., Ghassemian, Majid, Bandeira, Nuno, Komives, Elizabeth A.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Biochemistry and Molecular Biology 2014
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945911/
https://ncbi.nlm.nih.gov/pubmed/24425750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M113.034710
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