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Catalytic and binding poly-reactivities shared by two unrelated proteins: The potential role of promiscuity in enzyme evolution

It is generally accepted that enzymes evolved via gene duplication of existing proteins. But duplicated genes can serve as a starting point for the evolution of a new function only if the protein they encode happens to exhibit some activity towards this new function. Although the importance of such...

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Autors principals: James, Leo C., Tawfik, Dan S.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2001
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374036/
https://ncbi.nlm.nih.gov/pubmed/11714928
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