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Thermal and urea-induced unfolding in T7 RNA polymerase: Calorimetry, circular dichroism and fluorescence study

Structural changes in T7 RNA polymerase (T7RNAP) induced by temperature and urea have been studied over a wide range of conditions to obtain information about the structural organization and the stability of the enzyme. T7RNAP is a large monomeric enzyme (99 kD). Calorimetric studies of the thermal...

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Detalhes bibliográficos
Main Authors: Griko, Yuri, Sreerama, Narasimha, Osumi-Davis, Patricia, Woody, Robert W., Woody, A-Young Moon
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373966/
https://ncbi.nlm.nih.gov/pubmed/11274475
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