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Crystal structures and increased stabilization of the protein G variants with switched folding pathways NuG1 and NuG2

We recently described two protein G variants (NuG1 and NuG2) with redesigned first hairpins that were almost twice as stable, folded 100-fold faster, and had a switched folding mechanism relative to the wild-type protein. To test the structural accuracy of our design algorithm and to provide insight...

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Main Authors: Nauli, Sehat, Kuhlman, Brian, Le Trong, Isolde, Stenkamp, Ronald E., Teller, David, Baker, David
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2002
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373753/
https://ncbi.nlm.nih.gov/pubmed/12441390
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