Construction of a fluorescent biosensor family

Bacterial periplasmic binding proteins (bPBPs) are specific for a wide variety of small molecule ligands. bPBPs undergo a large, ligand-mediated conformational change that can be linked to reporter functions to monitor ligand concentrations. This mechanism provides the basis of a general system for...

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Detalhes bibliográficos
Main Authors: De Lorimier, Robert M., Smith, J. Jeff, Dwyer, Mary A., Looger, Loren L., Sali, Kevin M., Paavola, Chad D., Rizk, Shahir S., Sadigov, Shamil, Conrad, David W., Loew, Leslie, Hellinga, Homme W.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373719/
https://ncbi.nlm.nih.gov/pubmed/12381848
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