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Structural basis for cyclodextrins' suppression of human growth hormone aggregation

Many therapeutic proteins require storage at room temperature for extended periods of time. This can lead to aggregation and loss of function. Cyclodextrins (CDs) have been shown to function as aggregation suppressors for a wide range of proteins. Their potency is often ascribed to their affinity fo...

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Bibliografski detalji
Glavni autori: Otzen, Daniel Erik, Knudsen, Benjamin Raerup, Aachmann, Finn, Larsen, Kim Lambertsen, Wimmer, Reinhard
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2002
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373647/
https://ncbi.nlm.nih.gov/pubmed/12070330
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