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Structural basis for cyclodextrins' suppression of human growth hormone aggregation

Many therapeutic proteins require storage at room temperature for extended periods of time. This can lead to aggregation and loss of function. Cyclodextrins (CDs) have been shown to function as aggregation suppressors for a wide range of proteins. Their potency is often ascribed to their affinity fo...

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Detalhes bibliográficos
Main Authors: Otzen, Daniel Erik, Knudsen, Benjamin Raerup, Aachmann, Finn, Larsen, Kim Lambertsen, Wimmer, Reinhard
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373647/
https://ncbi.nlm.nih.gov/pubmed/12070330
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