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Structural basis for cyclodextrins' suppression of human growth hormone aggregation

Many therapeutic proteins require storage at room temperature for extended periods of time. This can lead to aggregation and loss of function. Cyclodextrins (CDs) have been shown to function as aggregation suppressors for a wide range of proteins. Their potency is often ascribed to their affinity fo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Otzen, Daniel Erik, Knudsen, Benjamin Raerup, Aachmann, Finn, Larsen, Kim Lambertsen, Wimmer, Reinhard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2002
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373647/
https://ncbi.nlm.nih.gov/pubmed/12070330
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