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Development of a cytokine analog with enhanced stability using computational ultrahigh throughput screening

Granulocyte-colony stimulating factor (G-CSF) is used worldwide to prevent neutropenia caused by high-dose chemotherapy. It has limited stability, strict formulation and storage requirements, and because of poor oral absorption must be administered by injection (typically daily). Thus, there is sign...

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Hlavní autoři: Luo, Peizhi, Hayes, Robert J., Chan, Cheryl, Stark, Diane M., Hwang, Marian Y., Jacinto, Jonathan M., Juvvadi, Padmaja, Chung, Helen S., Kundu, Anirban, Ary, Marie L., Dahiyat, Bassil I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2002
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373568/
https://ncbi.nlm.nih.gov/pubmed/11967378
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