Genetic bottlenecks and population passages cause profound fitness differences in RNA viruses.

Repeated clone-to-clone (genetic bottleneck) passages of an RNA phage and vesicular stomatitis virus have been shown previously to result in loss of fitness due to Muller's ratchet. We now demonstrate that Muller's ratchet also operates when genetic bottleneck passages are carried out at 3...

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Bibliografiska uppgifter
I publikationen:J Virol
Huvudupphovsmän: Clarke, D K, Duarte, E A, Moya, A, Elena, S F, Domingo, E, Holland, J
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 1993
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237355/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8380072/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.1.222-228.1993
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