Genetic bottlenecks and population passages cause profound fitness differences in RNA viruses.

Repeated clone-to-clone (genetic bottleneck) passages of an RNA phage and vesicular stomatitis virus have been shown previously to result in loss of fitness due to Muller's ratchet. We now demonstrate that Muller's ratchet also operates when genetic bottleneck passages are carried out at 3...

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Detaylı Bibliyografya
Yayımlandı:J Virol
Asıl Yazarlar: Clarke, D K, Duarte, E A, Moya, A, Elena, S F, Domingo, E, Holland, J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 1993
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237355/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8380072/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.1.222-228.1993
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