Genetic bottlenecks and population passages cause profound fitness differences in RNA viruses.

Repeated clone-to-clone (genetic bottleneck) passages of an RNA phage and vesicular stomatitis virus have been shown previously to result in loss of fitness due to Muller's ratchet. We now demonstrate that Muller's ratchet also operates when genetic bottleneck passages are carried out at 37 rather t...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Clarke, D K, Duarte, E A, Moya, A, Elena, S F, Domingo, E, Holland, J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237355/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8380072/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.1.222-228.1993
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