The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5

Protein arginine methyltransferase 5 (PRMT5) targets nuclear and cytoplasmic proteins. Here, we identified a nuclear protein, called cooperator of PRMT5 (COPR5), involved in the nuclear functions of PRMT5. COPR5 tightly binds to PRMT5, both in vitro and in living cells, but not to other members of t...

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Detalles Bibliográficos
Main Authors: Lacroix, Matthieu, Messaoudi, Selma El, Rodier, Geneviève, Le Cam, Aphonse, Sardet, Claude, Fabbrizio, Eric
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2008
Assuntos:
Scientific Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373370/
https://ncbi.nlm.nih.gov/pubmed/18404153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.45
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