The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5

Protein arginine methyltransferase 5 (PRMT5) targets nuclear and cytoplasmic proteins. Here, we identified a nuclear protein, called cooperator of PRMT5 (COPR5), involved in the nuclear functions of PRMT5. COPR5 tightly binds to PRMT5, both in vitro and in living cells, but not to other members of t...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Lacroix, Matthieu, Messaoudi, Selma El, Rodier, Geneviève, Le Cam, Aphonse, Sardet, Claude, Fabbrizio, Eric
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2008
Sujets:
Scientific Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373370/
https://ncbi.nlm.nih.gov/pubmed/18404153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.45
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