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NEDD8 acts as a ‘molecular switch' defining the functional selectivity of VHL
The von Hippel–Lindau (VHL) tumour suppressor protein is important in the E3 ubiquitin ligase ECV (Elongin B/C–CUL2–VHL)-mediated destruction of hypoxia-inducible factor and the promotion of fibronectin (FN) extracellular matrix assembly. Although the precise molecular mechanism controlling the sele...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2008
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2373363/ https://ncbi.nlm.nih.gov/pubmed/18323857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.19 |
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