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An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells
Skp1-Cdc53/Cul1-F-box (SCF) complexes constitute a class of E3 ubiquitin ligases. Recently, a multiprotein complex containing pVHL, elongin C and Cul2 (VEC) was shown to structurally and functionally resemble SCF complexes. Cdc53 and the Cullins can become covalently linked to the ubiquitin-like mol...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1083969/ https://ncbi.nlm.nih.gov/pubmed/11818338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvf028 |
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