An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells

Skp1-Cdc53/Cul1-F-box (SCF) complexes constitute a class of E3 ubiquitin ligases. Recently, a multiprotein complex containing pVHL, elongin C and Cul2 (VEC) was shown to structurally and functionally resemble SCF complexes. Cdc53 and the Cullins can become covalently linked to the ubiquitin-like mol...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ohh, Michael, Kim, William Y., Moslehi, Javid J., Chen, Yuzhi, Chau, Vincent, Read, Margaret A., Kaelin, William G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2002
Pynciau:
Scientific Reports
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1083969/
https://ncbi.nlm.nih.gov/pubmed/11818338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvf028
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