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NEDD8 acts as a ‘molecular switch' defining the functional selectivity of VHL

The von Hippel–Lindau (VHL) tumour suppressor protein is important in the E3 ubiquitin ligase ECV (Elongin B/C–CUL2–VHL)-mediated destruction of hypoxia-inducible factor and the promotion of fibronectin (FN) extracellular matrix assembly. Although the precise molecular mechanism controlling the sele...

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Autors principals: Russell, Ryan C, Ohh, Michael
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373363/
https://ncbi.nlm.nih.gov/pubmed/18323857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.19
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