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Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system
TGF-β-induced Smad signal transduction from the membrane into the nucleus is not linear and unidirectional, but rather a dynamic network that couples Smad phosphorylation and dephosphorylation through continuous nucleocytoplasmic shuttling of Smads. To understand the quantitative behavior of this ne...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2373357/ https://ncbi.nlm.nih.gov/pubmed/18443295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710134105 |
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