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Mouse neurovirulence determinants of poliovirus type 1 strain LS-a map to the coding regions of capsid protein VP1 and proteinase 2Apro.

Poliovirus type 1 strain LS-a [PV1(LS-a)] is a OV variant adapted to mice by multiple passages through mouse and monkey tissues. To investigate the molecular basis underlying mouse neurovirulence of PV1(LS-a), a cDNA of the viral genome containing nucleotides 112 to 7441 was cloned, and the nucleoti...

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Udgivet i:J Virol
Principais autores: Lu, H H, Yang, C F, Murdin, A D, Klein, M H, Harber, J J, Kew, O M, Wimmer, E
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237193/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7933134/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.11.7507-7515.1994
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