Neutralization of primary human immunodeficiency virus type 1 isolates by the broadly reactive anti-V3 monoclonal antibody, 447-52D.

Human monoclonal antibody 447-52D binds to the V3 determinant of the human immunodeficiency virus type 1 (HIV-1) gp120 external glycoprotein. Its binding requires the expression of the GPxR sequence at the center of the V3 domain. HIV-1 variants that are adapted to replication in T-lymphoid cell lin...

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Bibliographic Details
Main Authors: Conley, A J, Gorny, M K, Kessler, J A, Boots, L J, Ossorio-Castro, M, Koenig, S, Lineberger, D W, Emini, E A, Williams, C, Zolla-Pazner, S
Format: Artigo
Language:Inglês
Published: 1994
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC237136/
https://ncbi.nlm.nih.gov/pubmed/7933081
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