Immunization with a soluble CD4-gp120 complex preferentially induces neutralizing anti-human immunodeficiency virus type 1 antibodies directed to conformation-dependent epitopes of gp120.

Preservation of the conformation of recombinant gp120 in an adjuvant, enabling it to elicit conformation-dependent, epitope-specific, broadly neutralizing antibodies, may be critical for the development of any gp120-based human immunodeficiency virus type 1 (HIV-1) vaccine. It was hypothesized that...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Kang, C Y, Hariharan, K, Nara, P L, Sodroski, J, Moore, J P
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236990/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7520095/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.9.5854-5862.1994
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