Immunization with a soluble CD4-gp120 complex preferentially induces neutralizing anti-human immunodeficiency virus type 1 antibodies directed to conformation-dependent epitopes of gp120.

Preservation of the conformation of recombinant gp120 in an adjuvant, enabling it to elicit conformation-dependent, epitope-specific, broadly neutralizing antibodies, may be critical for the development of any gp120-based human immunodeficiency virus type 1 (HIV-1) vaccine. It was hypothesized that...

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Bibliografische gegevens
Hoofdauteurs: Kang, C Y, Hariharan, K, Nara, P L, Sodroski, J, Moore, J P
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1994
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC236990/
https://ncbi.nlm.nih.gov/pubmed/7520095
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