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The genetics of gene expression: comparison of linkage scans using two phenotype normalization methods

The goal of this paper is to investigate the effects of normalization procedures for expression data on linkage results. We selected the two most commonly used expression data extraction and normalization methods, Affymetrix global scaling and dChip invariant. After applying these two methods in 355...

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Autori principali: de Andrade, Mariza, Atkinson, Elizabeth J, Fridley, Brooke L, Goode, Ellen L, McDonnell, Shannon, Liu-Mares, Wen, Rabe, Kari G, Sun, Zhifu, Slager, Susan L
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367553/
https://ncbi.nlm.nih.gov/pubmed/18466496
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