Lethality of PE2 incorporation into Sindbis virus can be suppressed by second-site mutations in E3 and E2.

Sindbis virions contain two glycoproteins, E1 and E2. E2 is produced initially as a precursor, PE2, from which the amino-terminal 64 amino acids are cleaved by a cellular protease at a late stage in virion maturation. A mutation at E2 position 1 (Arg to Asn) was placed into Sindbis virus AR339 by si...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Heidner, H W, McKnight, K L, Davis, N L, Johnston, R E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236746/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7908062/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.4.2683-2692.1994
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