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Lethality of PE2 incorporation into Sindbis virus can be suppressed by second-site mutations in E3 and E2.

Sindbis virions contain two glycoproteins, E1 and E2. E2 is produced initially as a precursor, PE2, from which the amino-terminal 64 amino acids are cleaved by a cellular protease at a late stage in virion maturation. A mutation at E2 position 1 (Arg to Asn) was placed into Sindbis virus AR339 by si...

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Detalhes bibliográficos
Main Authors: Heidner, H W, McKnight, K L, Davis, N L, Johnston, R E
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC236746/
https://ncbi.nlm.nih.gov/pubmed/7908062
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