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Lethality of PE2 incorporation into Sindbis virus can be suppressed by second-site mutations in E3 and E2.

Sindbis virions contain two glycoproteins, E1 and E2. E2 is produced initially as a precursor, PE2, from which the amino-terminal 64 amino acids are cleaved by a cellular protease at a late stage in virion maturation. A mutation at E2 position 1 (Arg to Asn) was placed into Sindbis virus AR339 by si...

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Udgivet i:J Virol
Principais autores: Heidner, H W, McKnight, K L, Davis, N L, Johnston, R E
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236746/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7908062/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.4.2683-2692.1994
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