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Effect of Fgd1 on Cortactin in Arp2/3 Complex-Mediated Actin Assembly

Mutations in faciogenital dysplasia protein (Fgd1) result in the human disease faciogenital dysplasia (FGDY). Fgd1 contains a RhoGEF domain specific for Cdc42. Fgd1 also contains a Src homology (SH3) binding domain (SH3-BD) that binds directly to the SH3 domain of cortactin, which promotes actin ass...

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Hlavní autoři: Kim, Kyoungtae, Hou, Peng, Gorski, Jerome L., Cooper, John A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2004
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2366894/
https://ncbi.nlm.nih.gov/pubmed/14992579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi036173t
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