Cholesterol Loss Enhances TrkB Signaling in Hippocampal Neurons Aging in Vitro

Binding of the neurotrophin brain-derived neurotrophic factor (BDNF) to the TrkB receptor is a major survival mechanism during embryonic development. In the aged brain, however, BDNF levels are low, suggesting that if TrkB is to play a role in survival at this stage additional mechanisms must have d...

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Hauptverfasser: Martin, Mauricio G., Perga, Simona, Trovò, Laura, Rasola, Andrea, Holm, Pontus, Rantamäki, Tomi, Harkany, Tibor, Castrén, Eero, Chiara, Federica, Dotti, Carlos G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2008
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2366859/
https://ncbi.nlm.nih.gov/pubmed/18287532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-09-0897
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