CD45RB Is a Novel Molecular Therapeutic Target to Inhibit Aβ Peptide-Induced Microglial MAPK Activation

BACKGROUND: Microglial activation, characterized by p38 MAPK or p44/42 MAPK pathway signal transduction, occurs in Alzheimer's disease (AD). Our previous studies demonstrated CD45, a membrane-bound protein tyrosine phosphatase (PTP), opposed β-amyloid (Aβ) peptide-induced microglial activation...

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Hlavní autoři: Zhu, Yuyan, Hou, Huayan, Nikolic, William V., Ehrhart, Jared, Rrapo, Elona, Bickford, Paula, Giunta, Brian, Tan, Jun
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2008
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2366070/
https://ncbi.nlm.nih.gov/pubmed/18478117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002135
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