The amino-terminal functions of the simian virus 40 large T antigen are required to overcome wild-type p53-mediated growth arrest of cells.
High levels of the p53 tumor suppressor protein can block progression through the cell cycle. A model system for the study of the mechanism of action of wild-type p53 is a cell line (T64-7B) derived from rat embryo fibroblasts transformed by activated ras and a temperature-sensitive murine p53 gene....
Enregistré dans:
| Publié dans: | J Virol |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology (ASM)
1994
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236587/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8107198/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.3.1334-1341.1994 |
| Tags: |
Pas de tags, Soyez le premier à ajouter un tag!
|