The amino-terminal functions of the simian virus 40 large T antigen are required to overcome wild-type p53-mediated growth arrest of cells.

High levels of the p53 tumor suppressor protein can block progression through the cell cycle. A model system for the study of the mechanism of action of wild-type p53 is a cell line (T64-7B) derived from rat embryo fibroblasts transformed by activated ras and a temperature-sensitive murine p53 gene....

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Quartin, R S, Cole, C N, Pipas, J M, Levine, A J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236587/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8107198/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.3.1334-1341.1994
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