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Cytotoxic Action of Carboxyborane Heterocyclic Amine Adducts

The heterocyclic carboxyborane amines were found to be potent cytotoxic agents in the murine L1210 lymphoid leukemia and human HeLa suspended carcinoma cells. These agents were observed to inhibit HeLa DNA topoisomerase II activity ~ 200 μM and L1210 topoisomerase II activity ≥ 100 μM. These agents...

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Autors principals: Miller, Merrill C., Sood, Anup, Spielvogel, Bernard F., Bastow, Ken, Hall, Iris H.
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 1997
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2365064/
https://ncbi.nlm.nih.gov/pubmed/18475792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/MBD.1997.229
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