Phase I and pharmacokinetic (PK) study of MAG-CPT (PNU 166148): a polymeric derivative of camptothecin (CPT)

Polymeric cytotoxic conjugates are being developed with the aim of preferential delivery of the anticancer agent to tumour. MAG-CPT comprises the topoisomerase I inhibitor camptothecin linked to a water-soluble polymeric backbone methacryloylglycynamide (average molecular weight 18 kDa, 10% CPT by w...

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Hlavní autoři: Bissett, D, Cassidy, J, de Bono, J S, Muirhead, F, Main, M, Robson, L, Fraier, D, Magnè, M L, Pellizzoni, C, Porro, M G, Spinelli, R, Speed, W, Twelves, C
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2004
Témata:
Clinical
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364737/
https://ncbi.nlm.nih.gov/pubmed/15187995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601922
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