Cytochrome P450 (CYP) 2J2 gene transfection attenuates MMP-9 via inhibition of NF-κβ in hyperhomocysteinemia

Hyperhomocysteinemia (HHcy) is associated with atherosclerotic events involving the modulation of arachidonic acid (AA) metabolism and the activation of matrix metalloproteinase-9 (MMP-9). Cytochrome P450 (CYP) epoxygenase- 2J2 (CYP2J2) is abundant in the heart endothelium, and its AA metabolites ep...

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Hlavní autoři: Moshal, Karni S., Zeldin, Darryl C., Sithu, Srinivas D., Sen, Utpal, Tyagi, Neetu, Kumar, Munish, Hughes, William M., Metreveli, Naira, Rosenberger, Dorothea S. E., Singh, Mahavir, Vacek, Thomas P., Rodriguez, Walter E., Ayotunde, Adeagbo, Tyagi, Suresh C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364732/
https://ncbi.nlm.nih.gov/pubmed/18181170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21356
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