Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands

Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis. Two pyrrole–imidazole polyamides were designed to bind DNA sequenc...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Dickinson, Liliane A., Gulizia, Richard J., Trauger, John W., Baird, Eldon E., Mosier, Donald E., Gottesfeld, Joel M., Dervan, Peter B.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23643/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9789010/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.22.12890
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