Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands

Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis. Two pyrrole–imidazole polyamides were designed to bind DNA sequenc...

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Hauptverfasser: Dickinson, Liliane A., Gulizia, Richard J., Trauger, John W., Baird, Eldon E., Mosier, Donald E., Gottesfeld, Joel M., Dervan, Peter B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 1998
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC23643/
https://ncbi.nlm.nih.gov/pubmed/9789010
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