Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors

The peroxisome proliferator-activated receptors (PPARs) are transcriptional regulators of glucose, lipid, and cholesterol metabolism. We report the x-ray crystal structure of the ligand binding domain of PPARα (NR1C1) as a complex with the agonist ligand GW409544 and a coactivator motif from the ste...

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書誌詳細

出版年:	Proc Natl Acad Sci U S A
主要な著者:	Xu, H. Eric, Lambert, Millard H., Montana, Valerie G., Plunket, Kelli D., Moore, Linda B., Collins, Jon L., Oplinger, Jeffery A., Kliewer, Steven A., Gampe, Robert T., McKee, David D., Moore, John T., Willson, Timothy M.
フォーマット:	Artigo
言語:	Inglês
出版事項:	National Academy of Sciences 2001
主題:	Biological Sciences
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC61142/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11698662/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.241410198
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