Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors

The peroxisome proliferator-activated receptors (PPARs) are transcriptional regulators of glucose, lipid, and cholesterol metabolism. We report the x-ray crystal structure of the ligand binding domain of PPARα (NR1C1) as a complex with the agonist ligand GW409544 and a coactivator motif from the ste...

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Detalhes bibliográficos
Main Authors: Xu, H. Eric, Lambert, Millard H., Montana, Valerie G., Plunket, Kelli D., Moore, Linda B., Collins, Jon L., Oplinger, Jeffery A., Kliewer, Steven A., Gampe, Robert T., McKee, David D., Moore, John T., Willson, Timothy M.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC61142/
https://ncbi.nlm.nih.gov/pubmed/11698662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241410198
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