Impact of thymidine phosphorylase surexpression on fluoropyrimidine activity and on tumour angiogenesis

Tumoral thymidine phosphorylase (TP) appears to play a dual role by being involved in neoangiogenesis and by activating 5FU prodrugs at the tumoral target site. The aim of the study was to investigate more thoroughly these potential physiological and pharmacological roles of TP. A rat carcinoma cell...

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Bibliographic Details
Main Authors: Marchetti, S, Chazal, M, Dubreuil, A, Fischel, J L, Etienne, M C, Milano, G
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2001
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364074/
https://ncbi.nlm.nih.gov/pubmed/11487278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.1908
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