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Impact of thymidine phosphorylase surexpression on fluoropyrimidine activity and on tumour angiogenesis
Tumoral thymidine phosphorylase (TP) appears to play a dual role by being involved in neoangiogenesis and by activating 5FU prodrugs at the tumoral target site. The aim of the study was to investigate more thoroughly these potential physiological and pharmacological roles of TP. A rat carcinoma cell...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2001
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2364074/ https://ncbi.nlm.nih.gov/pubmed/11487278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.1908 |
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