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Thymidine Phosphorylase Activity and Prodrug Effects in a Three-Dimensional Model of Angiogenesis : Implications for the Treatment of Ovarian Cancer
Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) is associated with angiogenesis and the progression of human ovarian cancer. The enzyme converts thymidine to thymine and 2′-deoxyribose-1-phosphate and can also metabolize the prodrug 5′-deoxy-5-fluorouridine (Furt...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Investigative Pathology
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1853412/ https://ncbi.nlm.nih.gov/pubmed/9811349 |
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