Nuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinoma

Thymidylate synthase (TS) is a key enzyme in DNA synthesis and is inhibited by metabolites of the chemotherapeutic agent 5-fluorouracil (5FU). Nuclear expression of TS in human tissue in vivo has not been characterised and its clinicopathological correlates in malignancy are unknown. 52 cases of pri...

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Main Authors: Wong, N A C S, Brett, L, Stewart, M, Leitch, A, Longley, D B, Dunlop, M G, Johnston, P G, Lessells, A M, Jodrell, D I
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2001
主題:
Regular Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364004/
https://ncbi.nlm.nih.gov/pubmed/11747337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.2175
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