Mechanism of sensitization of MDR cancer cells by Pluronic block copolymers: Selective energy depletion

This paper, for the first time, demonstrates that exposure of cells to the poly(ethylene oxide)-poly(propylene oxide) block copolymer, Pluronic P85, results in a substantial decrease in ATP levels selectively in MDR cells. Cells expressing high levels of functional P-glycoprotein (MCF-7/ADR, KBv; LL...

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Bibliografiske detaljer
Main Authors: Batrakova, E V, Li, S, Elmquist, W F, Miller, D W, Alakhov, V Y, Kabanov, A V
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364003/
https://ncbi.nlm.nih.gov/pubmed/11747344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.2165
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