Internalisation enhances photo-induced cytotoxicity of monoclonal antibody-phthalocyanine conjugates

Immunophototherapy of cancer combines the specificity of a monoclonal antibody (MAb) to an overexpressed tumor marker with the phototoxic properties of the conjugated dye. To analyze the potential role of internalisation of the dye on photo-induced cytotoxicity, we compared two target antigens, carc...

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Detalhes bibliográficos
Main Authors: Carcenac, M, Dorvillius, M, Garambois, V, Glaussel, F, Larroque, Ch, Langlois, R, Hynes, N E, van Lier, J E, Pèlegrin, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2001
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363963/
https://ncbi.nlm.nih.gov/pubmed/11742503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.2170
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