Transcriptional down-regulation of the retinoblastoma protein is associated with differentiation and apoptosis in human colorectal epithelial cells

The aim of this study was to investigate the regulation of Rb protein expression in relation to increased differentiation and induction of apoptosis in colonic epithelial cells. In vivo, Rb protein expression was found to be down-regulated towards the top of the normal colonic crypt, coincident with...

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Bibliographic Details
Main Authors: Guy, M, Moorghen, M, Bond, J A, Collard, T J, Paraskeva, C, Williams, A C
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2001
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363755/
https://ncbi.nlm.nih.gov/pubmed/11207048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1635
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