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Phase I dose-escalation and pharmacokinetic study of a novel folate analogue AG2034
The novel folate analogue AG2034, which was designed as an inhibitor of GARFT (glycinamide ribonucleotide formyltransferase), was evaluated in this phase I study under the auspices of The Cancer Research Campaign, UK. AG2034 blocks de novo purine synthesis through inhibition of GARFT. A total of 28...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2363746/ https://ncbi.nlm.nih.gov/pubmed/11161393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1601 |
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