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High dose methotrexate chemotherapy: pharmacokinetics, folate and toxicity in osteosarcoma patients

AIMS: To investigate the relationships between pretreatment folate concentrations, MTX pharmacokinetics and acute toxicities following high dose methotrexate (HD MTX) therapy. METHODS: MTX and its major extracellular metabolite 7-OH-MTX were measured in eight serum samples per HD MTX cycle in 65 con...

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Detaylı Bibliyografya
Asıl Yazarlar: Holmboe, Laila, Andersen, Anders M, Mørkrid, Lars, Slørdal, Lars, Hall, Kirsten Sundby
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248260/
https://ncbi.nlm.nih.gov/pubmed/21707700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.04054.x
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