Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridinehosphorylase

The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear. In this study, we found that UP overexpression by gene transfer, and the subsequent efficient metabolic activation of 5-fluorouracil (5-FU) by the ribonucl...

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Hlavní autoři: Cuq, P, Rouquet, C, Evrard, A, Ciccolini, J, Vian, L, Cano, J-P
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2001
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363689/
https://ncbi.nlm.nih.gov/pubmed/11401323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.1833
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