Stable transfectants of human MCF-7 breast cancer cells with increased levels of the human folate receptor exhibit an increased sensitivity to antifolates.

A major problem in cancer therapy is tumor drug resistance such as is found with antifolates (e.g., methotrexate [MTX]). We are specifically interested in the role of the human folate receptor (hFR) in MTX resistance. To investigate whether transfection of hFR results in increased MTX uptake and inc...

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Detalhes bibliográficos
Main Authors: Chung, K N, Saikawa, Y, Paik, T H, Dixon, K H, Mulligan, T, Cowan, K H, Elwood, P C
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC288097/
https://ncbi.nlm.nih.gov/pubmed/7682567
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