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Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients
Oral bioavailability of paclitaxel is very low, which is due to efficient transport of the drug by the intestinal drug efflux pump P-glycoprotein (P-gp). We have recently demonstrated that the oral bioavailability of paclitaxel can be increased at least 7-fold by co-administration of the P-gp blocke...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2001
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2363627/ https://ncbi.nlm.nih.gov/pubmed/11139311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1543 |
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